WEKO3
アイテム
天然多糖類による抗ウイルス性バイオ材料の開発
https://doi.org/10.19000/00007533
https://doi.org/10.19000/000075331cfb6e20-c767-4937-885b-b2827db8ad76
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Tegushi_Thesis.pdf (3.2 MB)
|
|
| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-03-18 | |||||
| タイトル | ||||||
| タイトル | Development of Antiviral Biomaterials by Naturally Occurring Polysaccharides | |||||
| 言語 | en | |||||
| タイトル | ||||||
| タイトル | 天然多糖類による抗ウイルス性バイオ材料の開発 | |||||
| 言語 | ja | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_db06 | |||||
| タイプ | doctoral thesis | |||||
| ID登録 | ||||||
| ID登録 | 10.19000/00007533 | |||||
| ID登録タイプ | JaLC | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
Tegshi, Muschin
× Tegshi, Muschin |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To develop a biomaterial with an influenza virus-adsorptive functionality, an alkyl curdlan sulfate was prepared by ionic interaction between a positively charged didodecyldimethyl ammonium bromide and a negatively charged sulfate group of curdlan sulfate, which has potent anti-HIV activity, and then coated on a membrane filter with a 1μm pore size by hydrophobic interaction with the long alkyl groups in the curdlan sulfate. The alkyl curdlan sulfate with the degree of alkylation (DOA) of 0.03 (1 didodecyldimethyl group/12 sugar residues with 36 hydroxyl or sulfate groups) showed potent anti-HIV activity in a 50% effective concentration (EC50) as low as 0.87 μg/ml (standard curdlan sulfate EC50 = 0.3 μg/ml), and the activity decreased with increasing DOA. A DOA higher than 0.1 (1 didodecyldimethyl group/three sugar residues with nine hydro xyl or sulfate groups) gave no anti-HIV activity. Although both curdlan sulfate and alkyl curdlan sulfates did not inhibited infection of MDCK cells by influenza viruses, the alkyl curdlan sulfate-coated |
|||||
| 言語 | en | |||||
| 書誌情報 |
p. 1 |
|||||
| 著者版フラグ | ||||||
| 言語 | en | |||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士（工学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 北見工業大学 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 10106甲第111号 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2011-09-09 | |||||
