{"_buckets": {"deposit": "7f640001-bdb1-4c01-8320-d4adba7028bf"}, "_deposit": {"id": "7539", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "7539"}, "status": "published"}, "_oai": {"id": "oai:kitami-it.repo.nii.ac.jp:00007539", "sets": []}, "author_link": ["38574"], "item_7_date_granted_63": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5", "attribute_value_mlt": [{"subitem_dategranted": "2011-09-09"}]}, "item_7_degree_grantor_61": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u6a5f\u95a2", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "\u5317\u898b\u5de5\u696d\u5927\u5b66"}]}]}, "item_7_degree_name_60": {"attribute_name": "\u5b66\u4f4d\u540d", "attribute_value_mlt": [{"subitem_degreename": "\u535a\u58eb\uff08\u5de5\u5b66\uff09"}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "To develop a biomaterial with an influenza virus-adsorptive functionality, an alkyl curdlan sulfate was prepared by ionic interaction between a positively charged didodecyldimethyl ammonium bromide and a negatively charged sulfate group of curdlan sulfate, which has potent anti-HIV activity, and then coated on a membrane filter with a 1\u03bcm pore size by hydrophobic interaction with the long alkyl groups in the curdlan sulfate. The alkyl curdlan sulfate with the degree of alkylation (DOA) of 0.03 (1 didodecyldimethyl group/12 sugar residues with 36 hydroxyl or sulfate groups) showed potent anti-HIV activity in a 50% effective concentration (EC50) as low as 0.87 \u03bcg/ml (standard curdlan sulfate EC50 = 0.3 \u03bcg/ml), and the activity decreased with increasing DOA.\nA DOA higher than 0.1 (1 didodecyldimethyl group/three sugar residues with nine hydro xyl or sulfate groups) gave no anti-HIV activity. Although both curdlan sulfate and alkyl curdlan sulfates did not inhibited infection of MDCK cells by influenza viruses, the alkyl curdlan sulfate-coated", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_7_dissertation_number_64": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "10106\u7532\u7b2c111\u53f7"}]}, "item_7_identifier_registration": {"attribute_name": "ID\u767b\u9332", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.19000/00007533", "subitem_identifier_reg_type": "JaLC"}]}, "item_7_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_7_subject_16": {"attribute_name": "\u65e5\u672c\u5341\u9032\u5206\u985e\u6cd5", "attribute_value_mlt": [{"subitem_subject": "460", "subitem_subject_scheme": "NDC"}]}, "item_access_right": {"attribute_name": "\u30a2\u30af\u30bb\u30b9\u6a29", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tegshi, Muschin", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "38574", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-11-22"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Tegushi_Thesis.pdf", "filesize": [{"value": "3.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 3200000.0, "url": {"label": "Tegushi_Thesis.pdf", "objectType": "fulltext", "url": "https://kitami-it.repo.nii.ac.jp/record/7539/files/Tegushi_Thesis.pdf"}, "version_id": "f4babcd4-a3af-478d-b8f1-bbc29974d6d0"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Development of Antiviral Biomaterials by Naturally Occurring Polysaccharides", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Development of Antiviral Biomaterials by Naturally Occurring Polysaccharides", "subitem_title_language": "en"}, {"subitem_title": "\u5929\u7136\u591a\u7cd6\u985e\u306b\u3088\u308b\u6297\u30a6\u30a4\u30eb\u30b9\u6027\u30d0\u30a4\u30aa\u6750\u6599\u306e\u958b\u767a", "subitem_title_language": "ja"}]}, "item_type_id": "7", "owner": "1", "path": ["2/6"], "permalink_uri": "https://doi.org/10.19000/00007533", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2013-03-18"}, "publish_date": "2013-03-18", "publish_status": "0", "recid": "7539", "relation": {}, "relation_version_is_last": true, "title": ["Development of Antiviral Biomaterials by Naturally Occurring Polysaccharides"], "weko_shared_id": -1}