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  1. 学位論文
  2. 博士論文

天然多糖類による抗ウイルス性バイオ材料の開発

https://doi.org/10.19000/00007533
1cfb6e20-c767-4937-885b-b2827db8ad76
名前 / ファイル ライセンス アクション
Tegushi_Thesis.pdf Tegushi_Thesis.pdf (3.2 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2013-03-18
タイトル
言語 en
タイトル Development of Antiviral Biomaterials by Naturally Occurring Polysaccharides
タイトル
言語 ja
タイトル 天然多糖類による抗ウイルス性バイオ材料の開発
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
ID登録
ID登録 10.19000/00007533
ID登録タイプ JaLC
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 Tegshi, Muschin

× Tegshi, Muschin

WEKO 38574

en Tegshi, Muschin

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抄録
内容記述タイプ Abstract
内容記述 To develop a biomaterial with an influenza virus-adsorptive functionality, an alkyl curdlan sulfate was prepared by ionic interaction between a positively charged didodecyldimethyl ammonium bromide and a negatively charged sulfate group of curdlan sulfate, which has potent anti-HIV activity, and then coated on a membrane filter with a 1μm pore size by hydrophobic interaction with the long alkyl groups in the curdlan sulfate. The alkyl curdlan sulfate with the degree of alkylation (DOA) of 0.03 (1 didodecyldimethyl group/12 sugar residues with 36 hydroxyl or sulfate groups) showed potent anti-HIV activity in a 50% effective concentration (EC50) as low as 0.87 μg/ml (standard curdlan sulfate EC50 = 0.3 μg/ml), and the activity decreased with increasing DOA.
A DOA higher than 0.1 (1 didodecyldimethyl group/three sugar residues with nine hydro xyl or sulfate groups) gave no anti-HIV activity. Although both curdlan sulfate and alkyl curdlan sulfates did not inhibited infection of MDCK cells by influenza viruses, the alkyl curdlan sulfate-coated
言語 en
著者版フラグ
値 ETD
学位名
学位名 博士(工学)
学位授与機関
学位授与機関名
学位授与機関名 北見工業大学
学位授与番号
学位授与番号 10106甲第111号
学位授与年月日
学位授与年月日 2011-09-09
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