{"created":"2021-03-01T05:59:59.547162+00:00","id":7539,"links":{},"metadata":{"_buckets":{"deposit":"7f640001-bdb1-4c01-8320-d4adba7028bf"},"_deposit":{"id":"7539","owners":[],"pid":{"revision_id":0,"type":"depid","value":"7539"},"status":"published"},"_oai":{"id":"oai:kitami-it.repo.nii.ac.jp:00007539","sets":["2:6"]},"author_link":["38574"],"item_7_date_granted_63":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2011-09-09"}]},"item_7_degree_grantor_61":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"北見工業大学"}]}]},"item_7_degree_name_60":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（工学）"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To develop a biomaterial with an influenza virus-adsorptive functionality, an alkyl curdlan sulfate was prepared by ionic interaction between a positively charged didodecyldimethyl ammonium bromide and a negatively charged sulfate group of curdlan sulfate, which has potent anti-HIV activity, and then coated on a membrane filter with a 1μm pore size by hydrophobic interaction with the long alkyl groups in the curdlan sulfate. The alkyl curdlan sulfate with the degree of alkylation (DOA) of 0.03 (1 didodecyldimethyl group/12 sugar residues with 36 hydroxyl or sulfate groups) showed potent anti-HIV activity in a 50% effective concentration (EC50) as low as 0.87 μg/ml (standard curdlan sulfate EC50 = 0.3 μg/ml), and the activity decreased with increasing DOA.\nA DOA higher than 0.1 (1 didodecyldimethyl group/three sugar residues with nine hydro xyl or sulfate groups) gave no anti-HIV activity. Although both curdlan sulfate and alkyl curdlan sulfates did not inhibited infection of MDCK cells by influenza viruses, the alkyl curdlan sulfate-coated","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_7_dissertation_number_64":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"10106甲第111号"}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.19000/00007533","subitem_identifier_reg_type":"JaLC"}]},"item_7_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"ETD"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tegshi, Muschin","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"38574","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-11-22"}],"displaytype":"detail","filename":"Tegushi_Thesis.pdf","filesize":[{"value":"3.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Tegushi_Thesis.pdf","objectType":"fulltext","url":"https://kitami-it.repo.nii.ac.jp/record/7539/files/Tegushi_Thesis.pdf"},"version_id":"f4babcd4-a3af-478d-b8f1-bbc29974d6d0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Development of Antiviral Biomaterials by Naturally Occurring Polysaccharides","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Development of Antiviral Biomaterials by Naturally Occurring Polysaccharides","subitem_title_language":"en"},{"subitem_title":"天然多糖類による抗ウイルス性バイオ材料の開発","subitem_title_language":"ja"}]},"item_type_id":"7","owner":"1","path":["6"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-03-18"},"publish_date":"2013-03-18","publish_status":"0","recid":"7539","relation_version_is_last":true,"title":["Development of Antiviral Biomaterials by Naturally Occurring Polysaccharides"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-13T02:21:00.750659+00:00"}