| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2016-11-21 |
| タイトル |
|
|
タイトル |
Preparation of optically active 4-substituted,γ-lactones by lipase-catalyzed optical resolution |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
enantioselective acetylation |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
enzymatic resolution |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Grignard reaction |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
γ-lactone |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
organolithium reagent |
| 資源タイプ |
|
|
資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Shimotori, Yasutaka
Hoshi, Masayuki
Inoue, Keita
Osanai, Takeshi
Okabe, Hayato
Miyakoshi, Tetsuo
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Optically active 4-substituted γ-lactones (3 and 4) were synthesized effectively using lipase-catalyzed optical resolution. N-methyl-4-hydroxyalkanamides (rac-1a?i) as substrates were prepared from N-methylsuccinimide. The alkylation of N-methylsuccinimide using Grignard reagents generated from various alkyl halides followed by reduction resulted in N-methyl-4-hydroxyalkanamides. The optical resolution of rac-1a?g was performed using Novozym 435-catalyzed stereoselective acetylation. The stereoselective preparation of 4-substituted γ-lactones (3 and 4) possessing various side chains such as isopentyl, phenyl, and phenethyl groups was achieved with more than 90% enantiopurity. |
| 書誌情報 |
Heterocyclic communications
巻 21,
号 3,
p. 165-174,
発行日 2015-06
|
| 権利 |
|
|
権利情報 |
c 2015 de Gruyter |
| 出版者 |
|
|
出版者 |
De Gruyter |
| 著者版フラグ |
|
|
言語 |
en |
|
値 |
publisher |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
No3.pdf (1.0 MB)
