Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2016-11-21 |
タイトル |
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タイトル |
Preparation of optically active 4-substituted,γ-lactones by lipase-catalyzed optical resolution |
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言語 |
en |
言語 |
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言語 |
eng |
キーワード |
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主題Scheme |
Other |
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主題 |
enantioselective acetylation |
キーワード |
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主題Scheme |
Other |
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主題 |
enzymatic resolution |
キーワード |
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主題Scheme |
Other |
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主題 |
Grignard reaction |
キーワード |
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主題Scheme |
Other |
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主題 |
γ-lactone |
キーワード |
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主題Scheme |
Other |
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主題 |
organolithium reagent |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
著者 |
Shimotori, Yasutaka
Hoshi, Masayuki
Inoue, Keita
Osanai, Takeshi
Okabe, Hayato
Miyakoshi, Tetsuo
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著者別名 |
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識別子Scheme |
WEKO |
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識別子 |
44800 |
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姓名 |
霜鳥, 慈岳 |
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言語 |
ja |
著者別名 |
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識別子Scheme |
WEKO |
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識別子 |
44871 |
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識別子Scheme |
KAKEN |
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識別子URI |
https://nrid.nii.ac.jp/ja/nrid/1000000113712 |
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識別子 |
113712 |
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姓名 |
星, 雅之 |
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言語 |
ja |
抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Optically active 4-substituted γ-lactones (3 and 4) were synthesized effectively using lipase-catalyzed optical resolution. N-methyl-4-hydroxyalkanamides (rac-1a?i) as substrates were prepared from N-methylsuccinimide. The alkylation of N-methylsuccinimide using Grignard reagents generated from various alkyl halides followed by reduction resulted in N-methyl-4-hydroxyalkanamides. The optical resolution of rac-1a?g was performed using Novozym 435-catalyzed stereoselective acetylation. The stereoselective preparation of 4-substituted γ-lactones (3 and 4) possessing various side chains such as isopentyl, phenyl, and phenethyl groups was achieved with more than 90% enantiopurity. |
書誌情報 |
Heterocyclic communications
巻 21,
号 3,
p. 165-174,
発行日 2015-06
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権利 |
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権利情報 |
c 2015 de Gruyter |
出版者 |
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出版者 |
De Gruyter |
著者版フラグ |
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言語 |
en |
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値 |
publisher |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |