@article{oai:kitami-it.repo.nii.ac.jp:00008489,
 author = {Shimotori, Yasutaka and Hoshi, Masayuki and Inoue, Keita and Osanai, Takeshi and Okabe, Hayato and Miyakoshi, Tetsuo},
 issue = {3},
 journal = {Heterocyclic communications},
 month = {Jun},
 note = {Optically active 4-substituted γ-lactones (3 and 4) were synthesized effectively using lipase-catalyzed optical resolution. N-methyl-4-hydroxyalkanamides (rac-1a?i) as substrates were prepared from N-methylsuccinimide. The alkylation of N-methylsuccinimide using Grignard reagents generated from various alkyl halides followed by reduction resulted in N-methyl-4-hydroxyalkanamides. The optical resolution of rac-1a?g was performed using Novozym 435-catalyzed stereoselective acetylation. The stereoselective preparation of 4-substituted γ-lactones (3 and 4) possessing various side chains such as isopentyl, phenyl, and phenethyl groups was achieved with more than 90% enantiopurity.},
 pages = {165--174},
 title = {Preparation of optically active 4-substituted,γ-lactones by lipase-catalyzed optical resolution},
 volume = {21},
 year = {2015}
}