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Prevention of Copper-Induced Calcium Influx and Cell Death by Prion-Derived Peptide in Suspension-Cultured Tobacco Cells
https://kitami-it.repo.nii.ac.jp/records/8867
https://kitami-it.repo.nii.ac.jp/records/88671d1a8da1-3df7-4f08-812f-0a9b71dcc17a
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-12-17 | |||||
タイトル | ||||||
タイトル | Prevention of Copper-Induced Calcium Influx and Cell Death by Prion-Derived Peptide in Suspension-Cultured Tobacco Cells | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Aequorin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Copper Phytotoxicity | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Prion Protein | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
Kagenishi, Tomoko
× Kagenishi, Tomoko× Yokawa, Ken× Kuse, Masaki× Isobe, Minoru× Bouteau, Francois× Kawano, Tomonori |
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著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 90254 | |||||
識別子Scheme | KAKEN - 研究者検索 | |||||
識別子URI | https://nrid.nii.ac.jp/ja/nrid/1000020815633/ | |||||
識別子 | 20815633 | |||||
姓名 | 蔭西, 知子 | |||||
言語 | ja | |||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 90253 | |||||
識別子Scheme | KAKEN - 研究者検索 | |||||
識別子URI | https://nrid.nii.ac.jp/ja/nrid/1000060750908/ | |||||
識別子 | 60750908 | |||||
姓名 | 陽川, 憲 | |||||
言語 | ja | |||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 90330 | |||||
識別子Scheme | KAKEN - 研究者検索 | |||||
識別子URI | https://nrid.nii.ac.jp/ja/nrid/1000020335699/ | |||||
識別子 | 20335699 | |||||
姓名 | 河野, 智謙 | |||||
言語 | ja | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Impact of copper on the oxidative and calcium signal transductions leading to cell death in plant cells and the effects of the copper-binding peptide derived from the human prion protein (PrP) as a novel plant-protecting agent were assessed using a cell suspension culture of transgenic tobacco (Nicotiana tabacum L., cell line BY-2) expressing the aequorin gene. Copper induces a series of biological and chemical reactions in plant cells including the oxidative burst reflecting the production of reactive oxygen species (ROS), such as hydroxyl radicals, and stimulation of calcium channel opening, allowing a transient increase in cytosolic calcium concentrations. The former was proven by the action of specifiC ROS scavengers blocking the calcium responses and the latter was proven by an increase in aequorin luminescence and its inhibition by specifi c channel blockers. Following these early events completed within 10 min, the development of copper-induced cell death was observed during additional 1 h in a dose-dependent manner. Addition of a synthetic peptide (KTNMKHMA) corresponding to the neurotoxic sequence in human PrP, prior to the addition of copper, effectively blocked both calcium influx and cell death induced by copper. Lastly, a possible mechanism of peptide action and future applications of this peptide in the protection of plant roots from metal toxicity or in favour of phytoremediation processes are discussed. | |||||
書誌情報 |
de : Zeitschrift fur Naturforschung C 巻 64, 号 5-6, p. 411-417, 発行日 2014 |
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ISSN | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 1865-7125 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1515/znc-2009-5-619 | |||||
権利 | ||||||
権利情報 | c 1946 ? 2014: Verlag der Zeitschrift fur Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. | |||||
出版者 | ||||||
出版者 | Walter de Gruyter GmbH | |||||
著者版フラグ | ||||||
言語 | en | |||||
値 | publisher | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |