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Protein release parameters estimated with a flow system on zinc-containing apatite
https://kitami-it.repo.nii.ac.jp/records/8796
https://kitami-it.repo.nii.ac.jp/records/87966bea5d54-db7c-48d8-ab90-00c9779c5099
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
IOP Conf. Series_Materials Sci & Eng_18(2011)_192016 (732.0 kB)
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| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-11-07 | |||||
| タイトル | ||||||
| タイトル | Protein release parameters estimated with a flow system on zinc-containing apatite | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_5794 | |||||
| タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
Inaba, M
× Inaba, M× 菅野 , 亨× Tada, K× Itabashi, K× Horiuchi, J× Akazawa, T |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Adsorption and desorption properties of proteins on zinc-containing apatite were successively monitored with a newly-developed flow system, and sustained-release ability of the apatite with different zinc contents was evaluated using protein release parameters we suggested. Three sustained-release parameters; initial desorption rate (rinit), time of desorption-completed (Tdes), and desorption constant (kd) were estimated with graphical analysis of dynamic desorption curves in a flow of 20 mM phosphate-buffered solution (PBS). Bovine serum albumin (BSA) of isoelectric point (pI) 4.8 and egg white lysozyme (LSZ) of pI 11.2 were employed as model protein drugs. Incorporation of zinc into hydroxyapatite changed desorption responses of the proteins. Zn(0.15), where the number in parentheses denoted the preparing molar ratio of Zn/Ca, showed the most sustained-release ability: less rinit, longer Tdes, and smaller kd. Furthermore, the adsorbed amounts of the proteins for Zn(0.15) were 1.5 ~ 4 times larger than Zn(0), which suggested that Zn(0.15) would be promising as a sustained-release carrier of protein drugs. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : IOP Conference Series: Materials Science and Engineering 巻 18, 号 19, p. 192016, 発行日 2011 |
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| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 1757-899X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1088/1757-899X/18/19/192016 | |||||
| 著者版フラグ | ||||||
| 言語 | en | |||||
| 値 | publisher | |||||
| 出版者 | ||||||
| 出版者 | IOP Publishing | |||||
