| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-12-17 |
| タイトル |
|
|
タイトル |
Copper-Binding Peptides from Human Prion Protein and Newly Designed Peroxidative Biocatalysts |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Artifi cial Enzyme |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Peroxidase |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
PrP |
| 資源タイプ |
|
|
資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Kagenishi, Tomoko
Yokawa, Ken
Kadono, Takashi
Uezu, Kazuya
Kawano, Tomonori
|
| 著者別名 |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
90254 |
|
|
識別子Scheme |
KAKEN - 研究者検索 |
|
|
識別子URI |
https://nrid.nii.ac.jp/ja/nrid/1000020815633/ |
|
|
識別子 |
20815633 |
|
|
姓名 |
蔭西, 知子 |
|
|
言語 |
ja |
| 著者別名 |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
90253 |
|
|
識別子Scheme |
KAKEN - 研究者検索 |
|
|
識別子URI |
https://nrid.nii.ac.jp/ja/nrid/1000060750908/ |
|
|
識別子 |
60750908 |
|
|
姓名 |
陽川, 憲 |
|
|
言語 |
ja |
| 著者別名 |
|
|
|
識別子Scheme |
WEKO |
|
|
識別子 |
90330 |
|
|
識別子Scheme |
KAKEN - 研究者検索 |
|
|
識別子URI |
https://nrid.nii.ac.jp/ja/nrid/1000020335699/ |
|
|
識別子 |
20335699 |
|
|
姓名 |
河野, 智謙 |
|
|
言語 |
ja |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
A previous work suggested that peptides from the histidine-containing copper-binding motifs in human prion protein (PrP) function as peroxidase-like biocatalysts catalyzing the generation of superoxide anion radicals in the presence of neurotransmitters (aromatic monoamines) and phenolics such as tyrosine and tyrosyl residues on proteins. In this study, using various phenolic substrates, the phenol-dependent superoxide-generating activities of PrP-derived peptide sequences were compared. Among the peptides tested, the GGGTH pentapeptide was shown to be the most active catalyst for phenol-dependent reactions. Based on these results, we designed a series of oligoglycyl-histidines as novel peroxidative biocatalysts, and their catalytic performances including kinetics, heat tolerance, and freezing tolerance were analysed. |
| 書誌情報 |
de : Zeitschrift fur Naturforschung C
巻 66,
号 3-4,
p. 182-190,
発行日 2011
|
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1865-7125 |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1515/znc-2011-3-413 |
| 権利 |
|
|
権利情報 |
c 1946 ? 2014: Verlag der Zeitschrift fur Naturforschung. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. |
| 出版者 |
|
|
出版者 |
Walter de Gruyter GmbH |
| 著者版フラグ |
|
|
言語 |
en |
|
値 |
publisher |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
Zeitschrift fur Naturforschung C,66(3-4), P182-190.pdf (469 KB)
.png)
