@article{oai:kitami-it.repo.nii.ac.jp:00007977,
 author = {Shimotori, Yasutaka and Hoshi, Masayuki and Miyakoshi, Tetsuo},
 issue = {5},
 journal = {Journal of Oleo Science  64(5), 561-575},
 month = {},
 note = {A new enzymatic method for synthesis of enantiomerically enriched δ-hexadecalactone (3) based on the enzymatic kinetic resolution of N-methyl-5-acetoxyhexadecanamide (1) is described. A combination of lipase-catalyzed hydrolysis and amidation improved enantioselectivity. Lipase-catalyzed amidation was also investigated. Detailed screening of solvents and additive amines was performed. The addition of cyclohexylamine to lipase-catalyzed hydrolysis afforded the best results to give both enantiomers of 3 with more than 90% enantiomeric excess.},
 pages = {561--575},
 title = {Combination of Novozym 435-catalyzed enantioselective hydrolysis and amidation for the preparation of optically active δ-hexadecalactone},
 volume = {64},
 year = {2015}
}