{"created":"2024-04-26T04:46:41.374590+00:00","id":2000618,"links":{},"metadata":{"_buckets":{"deposit":"4d3ba8ab-ed88-4441-8d39-0a10957ddd43"},"_deposit":{"created_by":15,"id":"2000618","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000618"},"status":"published"},"_oai":{"id":"oai:kitami-it.repo.nii.ac.jp:02000618","sets":["2:6"]},"author_link":[],"control_number":"2000618","item_7_alternative_title_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"気泡を用いる分離・精製技術の開発","subitem_alternative_title_language":"ja"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-03","bibliographicIssueDateType":"Issued"}}]},"item_7_date_granted_63":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2024-03-18"}]},"item_7_degree_grantor_61":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"北見工業大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"10106","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_60":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（工学）"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It was found that the air-water interface (air-bubbles) could be used as a separation medium for the purification of dyes and pharmaceuticals. Air bubbles are a harmless, waste-free medium with a low environmental impact. This study suggests that the air-water interface has solvent properties comparable to those of ethyl acetate and is effective in the purification of the basic dye Rhodamine B and the anti-malarial drug Chloroquine, providing the basis for a possible new method of compounds separation and purification.\nIn Chapter 2, the hydrophobic properties of bubbles as separation media were clarified by analysis using fluorescent probes and ultrafine bubbles (UFB), which are stable in water. Measurements using the fluorescent molecule 1,2'-dinaphthylamine, which is used to evaluate hydrophobic field, observed that water containing UFB is a much more hydrophobic solvent than water. The hydrophobicity of the bubbles was similar to that of ethyl acetate and diethyl ether, indicating the characteristics of bubbles as separation media.\nChapter 3 shows a rapid purification method for chloroquine based on flotation. Chloroquine, an antimalarial drug, is synthesized in about 80% yield by 4-amino-1diethylaminopentane and 4,7-dichloroquinoline. It has been purified by solvent extraction and then recrystallization. The method designed utilizes the differences in hydrophobicity and ionicity between the source material and the product, achieving a rapid separation in less than 10 minutes. The purity of the product was more than 99% by HPLC analysis. The use of bubbles as a separation medium has been shown to provide low environmental impact pharmaceuticals purification.\nChapter 4 was a fundamental study for industrial continuous treatment combined with microfiltration (MF). MF membranes have the advantage of good permeability and resistance to fouling, but their large pore size prevents them from blocking low molecular compounds such as dyes. We found that a specific dye can be blocked by passing a solution containing bubbles larger than the membrane pore size through an MF membrane, taking advantage of the properties of bubbles.\nAir-bubbles as a separation medium were found to have solvent properties similar to ethyl acetate and could rapidly adsorb and separate compounds with strong hydrophobic properties. it is even possible to prevent the permeation of compounds into the microfiltration membrane by means of adsorption of molecules on the bubbles. It is hoped that this research will provide the beginnings of a new low environmental impact separation method that could contribute to a sustainable society.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_7_dissertation_number_64":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第213号"}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.19000/0002000618","subitem_identifier_reg_type":"JaLC"}]},"item_7_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"ETD","subitem_select_language":"en"}]},"item_7_text_66":{"attribute_name":"研究科・専攻名","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"生産基盤工学専攻"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"児玉, 康輝","creatorNameLang":"ja"},{"creatorName":"コダマ, コウキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kodama, Koki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-04-26"}],"filename":"甲213_児玉 康輝.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://kitami-it.repo.nii.ac.jp/record/2000618/files/甲213_児玉 康輝.pdf"},"version_id":"a9c13c68-2707-451e-a0ff-208c8994699f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Development of Air Bubble-Mediated Separation and Purification Methods","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Development of Air Bubble-Mediated Separation and Purification Methods","subitem_title_language":"en"}]},"item_type_id":"7","owner":"15","path":["6"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-04-26"},"publish_date":"2024-04-26","publish_status":"0","recid":"2000618","relation_version_is_last":true,"title":["Development of Air Bubble-Mediated Separation and Purification Methods"],"weko_creator_id":"15","weko_shared_id":3},"updated":"2024-04-30T00:21:29.395411+00:00"}