2024-03-28T09:15:54Z
https://kitami-it.repo.nii.ac.jp/oai
oai:kitami-it.repo.nii.ac.jp:00008880
2022-12-13T02:22:27Z
1:87
Thermo-Stable Nature of Aromatic Monoamine-Dependent Superoxide-Generating Activity of Human Prion-Derived Cu-Binding Peptides
YOKAWA, Ken
KAGENISHI, Tomoko
KAWANO, Tomonori
prion protein
reactive oxygen species
heattolerance
freezing tolerant
Human prion protein has four distinct Cu-binding motifs that catalyze the generation of superoxide coupled to oxidation of phenols and amines. Here, the thermostability of the superoxide-generating prion-derived peptides was tested. Among the peptides tested, two maintained high catalytic activity even after heating and repeated freezing/thawing cycles. The biological roles for these thermostable catalysts are discussed.
Taylor & Francis
2014
eng
journal article
AM
https://kitami-it.repo.nii.ac.jp/records/8880
19420682
https://doi.org/10.1271/bbb.90012
0916-8451
Bioscience, Biotechnology, and Biochemistry
73
5
1218
1220
https://kitami-it.repo.nii.ac.jp/record/8880/files/Bioscience, Biotechnology, and Biochemistry, 73.5, 1218-1220.pdf
application/pdf
251.6 kB
2019-12-18